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Article

Genetic Modifiers of the p53 Pathway.

Cold Spring Harbor perspectives in medicine - 1 Apr 2016

Basu Subhasree, Murphy Maureen E

Abstract excerpt

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer; this gene is subject to inactivation by mutation or deletion in >50% of sporadic cancers. Genes that encode proteins that regulate p53 function, such as MDM2, MDM4, and CDKN2A (p14(ARF)) are also frequently altered in tumors, and it is generally believed that the p53 pathway is likely to be inactivated by mutation in close to 100%...

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Source

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Identifiers

PMID: 27037420
DOI: 10.1101/cshperspect.a026302
PMCID: PMC4817744

Genes

MDM2
MDM4
KITLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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