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Spontaneous and inherited TP53 genetic alterations

13 Aug 2021

Abstract excerpt

The p53 protein is a transcription factor that prevents tumors from developing. In spontaneous and inherited cancers there are many different missense mutations in the DNA binding domain of the TP53 gene that contributes to tumor formation. These mutations produce a wide distribution in the transcriptional capabilities of the mutant p53 proteins with over four logs differences in the efficiencies of forming...

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PMID: 34389799
DOI: 10.1038/s41388-021-01991-3

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