Article
The importance of p53 pathway genetics in inherited and somatic cancer genomes.
Nature reviews. Cancer - 1 Apr 2016
Stracquadanio Giovanni, Wang Xuting, Wallace Marsha D, Grawenda Anna M, Zhang Ping, Hewitt Juliet, Zeron-Medina Jorge, Castro-Giner Francesc, Tomlinson Ian P, Goding Colin R, Cygan Kamil J, Fairbrother William G, Thomas Laurent F, Sætrom Pål, Gemignani Federica, Landi Stefano, Schuster-Böckler Benjamin, Bell Douglas A, Bond Gareth L
Abstract excerpt
Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.