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Article

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

14 Nov 2003

Abstract excerpt

The glucocorticoid receptor (GR) activates or represses transcription depending on the sequence and architecture of the glucocorticoid response elements in target genes and the availability and activity of interacting cofactors. Numerous GR cofactors have been identified, but they alone are insufficient to dictate the specificity of GR action. Furthermore, the role of different functional surfaces on the receptor...

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PMID: 14617768
DOI: 10.1073/pnas.2336092100

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