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Article

Secretion of human epidermal growth factor from Saccharomyces cerevisiae using synthetic leader sequences.

Gene - 15 Oct 1991

Clements J M, Catlin G H, Price M J, Edwards R M

Abstract excerpt

We have investigated different leader sequences for their ability to direct the efficient secretion of human epidermal growth factor (hEGF) from Saccharomyces cerevisiae. We designed a consensus signal sequence which directs secretion of hEGF from yeast as efficiently as the yeast invertase signal sequence. However, secretion is increased over fivefold by the introduction, after the signal sequence, of a...

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PMID: 1937055
DOI: 10.1016/0378-1119(91)90209-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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