Directed evolution of a secretory leader for the improved expression of heterologous proteins and full‐length antibodies in <i>Saccharomyces cerevisiae</i>

Abstract excerpt

Because of its eukaryotic nature, simple fermentation requirements, and pliable genetics, there have been many attempts at improving recombinant protein production in Saccharomyces cerevisiae. These strategies typically involve altering the expression of a native protein thought to be involved in heterologous protein trafficking. Usually, these approaches yield three- to tenfold improvements over wild-type...

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