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Article

Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila.

Structure (London, England : 1993) - 15 Apr 2009

Raychaudhury Suchismita, Farelli Jeremiah D, Montminy Timothy P, Matthews Miguelina, Ménétret Jean-François, Duménil Guillaume, Roy Craig R, Head James F, Isberg Ralph R, Akey Christopher W

Abstract excerpt

During infection, Legionella pneumophila creates a replication vacuole within eukaryotic cells and this requires a Type IVb secretion system (T4bSS). IcmQ plays a critical role in the translocase and associates with IcmR. In this paper, we show that the N-terminal domain of IcmQ (Qn) mediates self-dimerization, whereas the C-terminal domain with a basic linker promotes membrane association. In addition, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19368892
DOI: 10.1016/j.str.2009.02.011
PMCID: PMC2693034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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