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Article

Coevolution between nonhomologous but functionally similar proteins and their conserved partners in the Legionella pathogenesis system.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2005

Feldman Michal, Zusman Tal, Hagag Shelly, Segal Gil

Abstract excerpt

Legionella pneumophila, the causative agent of Legionnaires' disease, and other pathogenic Legionella species multiply inside protozoa and human macrophages by using the intracellular multiplication (Icm)/defect in organelle trafficking (Dot) type-IV secretion system. The IcmQ protein, which possesses pore-forming activity, and IcmR, which regulates the IcmQ activity, are two essential components of this system....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16091472
DOI: 10.1073/pnas.0501850102
PMCID: PMC1189309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Coevolution between nonhomologous but functionally similar proteins and their conserved partners in the Legionella pathogenesis system.PMID 16091472Read ↗

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