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Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5

10 Nov 2017

Abstract excerpt

Abstract Legionella pneumophilacan cause Legionnaires’ disease and replicates intracellularly in a distinctLegionella-containing vacuole (LCV). LCV formation is a complex process that involves a plethora of type IV-secreted effector proteins. The effector RidL binds the Vps29 retromer subunit, blocks retrograde vesicle trafficking, and promotes intracellular bacterial replication. Here, we reveal that the 29-kDa...

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PMID: 29146912
DOI: 10.1038/s41467-017-01512-5

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