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Article

Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei.

Scientific reports - 4 Feb 2015

Lim Yan Ting, Jobichen Chacko, Wong Jocelyn, Limmathurotsakul Direk, Li Shaowei, Chen Yahua, Raida Manfred, Srinivasan Nalini, MacAry Paul Anthony, Sivaraman J, Gan Yunn-Hwen

Abstract excerpt

The Type VI Secretion System cluster 1 (T6SS1) is essential for the pathogenesis of Burkholderia pseudomallei, the causative agent of melioidosis, a disease endemic in the tropics. Inside host cells, B. pseudomallei escapes into the cytosol and through T6SS1, induces multinucleated giant cell (MNGC) formation that is thought to be important for bacterial cell to cell spread. The hemolysin-coregulated protein...

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Identifiers

PMID: 25648885
DOI: 10.1038/srep08235
PMCID: PMC4650826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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