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Article

Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2011

Sun Hua, Schlondorff Johannes S, Brown Elizabeth J, Higgs Henry N, Pollak Martin R

Abstract excerpt

Inverted formin 2 (INF2) encodes a member of the diaphanous subfamily of formin proteins. Mutations in INF2 cause human kidney disease characterized by focal and segmental glomerulosclerosis. Disease-causing mutations occur only in the diaphanous inhibitory domain (DID), suggesting specific roles for this domain in the pathogenesis of disease. In a yeast two-hybrid screen, we identified the diaphanous...

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Share to Glomerulosclerosis, Focal Segmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21278336
DOI: 10.1073/pnas.1017010108
PMCID: PMC3041098

Genes

INF2
SRF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).PMID 21278336Read ↗

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FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.Semantic proximity Read ↗

The formin INF2 in disease: progress from 10 years of research.Semantic proximity Read ↗

Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain.Semantic proximity Read ↗

Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis.Semantic proximity Read ↗

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1.Semantic proximity Read ↗

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Role of formin INF2 in human diseases.Semantic proximity Read ↗

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.Semantic proximity Read ↗

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