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Article

Gene-environment interaction tests for dichotomous traits in trios and sibships.

Genetic epidemiology - 1 Dec 2009

Hoffmann Thomas J, Lange Christoph, Vansteelandt Stijn, Laird Nan M

Abstract excerpt

When testing for genetic effects, failure to account for a gene-environment interaction can mask the true association effects of a genetic marker with disease. Family-based association tests are popular because they are completely robust to population substructure and model misspecification. However, when testing for an interaction, failure to model the main genetic effect correctly can lead to spurious results....

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Identifiers

PMID: 19365860
DOI: 10.1002/gepi.20421
PMCID: PMC3082448

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