Article
An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes.
European journal of human genetics : EJHG - 1 Jun 2010
Lasky-Su Jessica, Murphy Amy, McQueen Matthew B, Weiss Scott, Lange Christoph
Abstract excerpt
We propose an omnibus family-based association test (MFBAT) that can be applied to multiple markers and multiple phenotypes and that has only one degree of freedom. The proposed test statistic extends current FBAT methodology to incorporate multiple markers as well as multiple phenotypes. Using simulation studies, power estimates for the proposed methodology are compared with the standard methodologies. On the...
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