Article
Incorporating gene-environment interaction in testing for association with rare genetic variants.
Human heredity - 1 Jan 2014
Chen Han, Meigs James B, Dupuis Josée
Abstract excerpt
OBJECTIVES: The incorporation of gene-environment interactions could improve the ability to detect genetic associations with complex traits. For common genetic variants, single-marker interaction tests and joint tests of genetic main effects and gene-environment interaction have been well-established and used to identify novel association loci for complex diseases and continuous traits. For rare genetic variants,...
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