Article
Identification of CYP2D6 impaired functional alleles in Mexican Americans.
European journal of clinical pharmacology - 1 Dec 2005
Luo Huai-Rong, Gaedigk Andrea, Aloumanis Vasileios, Wan Yu-Jui Yvonne
Abstract excerpt
OBJECTIVES: To extend the genotyping analysis of the CYP2D6 gene and further explain variability of CYP2D6 activity in Mexican Americans by genetic factors. METHODS: CYP2D6 gene sequence variations associated with *6, *7, *8, *9, *11, *14, *29, *41, *45, and *46 alleles as well as the 2988G>A SNP were examined in 264 Mexican Americans; 236 had previously been phenotyped with dextromethorphan. All subjects were...
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