A self-scaffolding model for G protein signaling.

Abstract excerpt

Activation of heterotrimeric G proteins is generally believed to induce dissociation of Galpha and Gbetagamma subunits, which are then free to bind to and change the catalytic activity of a variety of intracellular enzymes. We have previously found that in cells, Galphaq subunits remain complexed with its major effector, phospholipase Cbeta1, through the activation cycle. To determine whether this behavior may be...

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