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Article

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.

The Journal of biological chemistry - 24 Feb 2006

Tang Wei, Tu Yaping, Nayak Surendra K, Woodson Jimmy, Jehl Markus, Ross Elliott M

Abstract excerpt

Gbetagamma subunits modulate several distinct molecular events involved with G protein signaling. In addition to regulating several effector proteins, Gbetagamma subunits help anchor Galpha subunits to the plasma membrane, promote interaction of Galpha with receptors, stabilize the binding of GDP to Galpha to suppress spurious activation, and provide membrane contact points for G protein-coupled receptor kinases....

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Share to GTP-Binding Protein alpha Subunits, Gi-Go

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Source

Identifiers

PMID: 16407201
DOI: 10.1074/jbc.M510573200

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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