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Article

Genetic background effects in Neuroligin-3 mutant mice: Minimal behavioral abnormalities on C57 background.

Autism research : official journal of the International Society for Autism Research - 1 Feb 2018

Jaramillo Thomas C, Escamilla Christine Ochoa, Liu Shunan, Peca Lauren, Birnbaum Shari G, Powell Craig M

Abstract excerpt

Neuroligin-3 (NLGN3) is a postsynaptic cell adhesion protein that interacts with presynaptic ligands including neurexin-1 (NRXN1) [Ichtchenko et al., Journal of Biological Chemistry, 271, 2676-2682, 1996]. Mice harboring a mutation in the NLGN3 gene (NL3R451C) mimicking a mutation found in two brothers with autism spectrum disorder (ASD) were previously generated and behaviorally phenotyped for autism-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29028156
DOI: 10.1002/aur.1857
PMCID: PMC5825258

Genes

NLGN3
NRXN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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