Article
Mice with an autism-associated R451C mutation in neuroligin-3 show a cautious but accurate response style in touchscreen attention tasks.
Genes, brain, and behavior - 1 Jan 2022
Burrows Emma L, May Carlos, Hill Thomas, Churliov Leonid, Johnson Katherine A, Hannan Anthony J
Abstract excerpt
One of the earliest identifiable features of autism spectrum disorder (ASD) is altered attention. Mice expressing the ASD-associated R451C mutation in synaptic adhesion protein neuroligin-3 (NL3) exhibit impaired reciprocal social interactions and repetitive and restrictive behaviours. The role of this mutation in attentional abnormalities has not been established. We assessed attention in male NL3R451C mice...
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