Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.

doi:10.1038/s41467-021-22059-6

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Article

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.

Nature communications - 23 Mar 2021

Yoshida Tomoyuki, Yamagata Atsushi, Imai Ayako, Kim Juhyon, Izumi Hironori, Nakashima Shogo, Shiroshima Tomoko, Maeda Asami, Iwasawa-Okamoto Shiho, Azechi Kenji, Osaka Fumina, Saitoh Takashi, Maenaka Katsumi, Shimada Takashi, Fukata Yuko, Fukata Masaki, Matsumoto Jumpei, Nishijo Hisao, Takao Keizo, Tanaka Shinji, Okabe Shigeo, Tabuchi Katsuhiko, Uemura Takeshi, Mishina Masayoshi, Mori Hisashi, Fukai Shuya

Abstract excerpt

Neuroligin 3 (NLGN3) and neurexins (NRXNs) constitute a canonical transsynaptic cell-adhesion pair, which has been implicated in autism. In autism spectrum disorder (ASD) development of sociality can be impaired. However, the molecular mechanism underlying NLGN3-mediated social development is unclear. Here, we identify non-canonical interactions between NLGN3 and protein tyrosine phosphatase δ (PTPδ) splice...

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PMID: 33758193
DOI: 10.1038/s41467-021-22059-6
PMCID: PMC7988105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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