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Article

High resolution magnetic resonance imaging for characterization of the neuroligin-3 knock-in mouse model associated with autism spectrum disorder.

PloS one - 1 Jan 2014

Kumar Manoj, Duda Jeffery T, Hwang Wei-Ting, Kenworthy Charles, Ittyerah Ranjit, Pickup Stephen, Brodkin Edward S, Gee James C, Abel Ted, Poptani Harish

Abstract excerpt

Autism spectrum disorders (ASD) comprise an etiologically heterogeneous set of neurodevelopmental disorders. Neuroligin-3 (NL-3) is a cell adhesion protein that mediates synapse development and has been implicated in ASD. We performed ex-vivo high resolution magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI) and behavioral (social approach and zero maze) tests at 3 different time points...

Topics

Animals
Autism Spectrum Disorder
Brain
Cell Adhesion Molecules, Neuronal
Diffusion Tensor Imaging
Disease Models, Animal
Gene Knock-In Techniques
Humans
Magnetic Resonance Imaging
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Nerve Tissue Proteins

Radiography

Source

Open in PubMed Open full text

Identifiers

PMID: 25299583
DOI: 10.1371/journal.pone.0109872
PMCID: PMC4192590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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