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Article

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.

Science (New York, N.Y.) - 5 Oct 2007

Tabuchi Katsuhiko, Blundell Jacqueline, Etherton Mark R, Hammer Robert E, Liu Xinran, Powell Craig M, Südhof Thomas C

Abstract excerpt

Autism spectrum disorders (ASDs) are characterized by impairments in social behaviors that are sometimes coupled to specialized cognitive abilities. A small percentage of ASD patients carry mutations in genes encoding neuroligins, which are postsynaptic cell-adhesion molecules. We introduced one of these mutations into mice: the Arg451-->Cys451 (R451C) substitution in neuroligin-3. R451C mutant mice showed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17823315
DOI: 10.1126/science.1146221
PMCID: PMC3235367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.PMID 17823315Read ↗

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