Article
Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism.
Neural plasticity - 1 Jan 2017
Burrows E L, Eastwood A F, May C, Kolbe S C, Hill T, McLachlan N M, Churilov L, Hannan A J
Abstract excerpt
Autism spectrum disorder (ASD) is a neurodevelopmental disorder typified by impaired social communication and restrictive and repetitive behaviors. Mice serve as an ideal candidate organism for studying the neural mechanisms that subserve these symptoms. The Neuroligin-3 (NL3) mouse, expressing a R451C mutation discovered in two Swedish brothers with ASD, exhibits impaired social interactions and heightened...
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