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Article

Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.

Molecular psychiatry - 1 Oct 2005

Sheehan K, Lowe N, Kirley A, Mullins C, Fitzgerald M, Gill M, Hawi Z

Abstract excerpt

Genetic and pharmacological studies have emphasised the role of serotonin 5-hydroxytryptamine (5-HT) as a possible etiologic factor in the development of attention-deficit hyperactivity disorder (ADHD). Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the biosynthesis of serotonin from tryptophan. Originally, the TPH gene was thought to be widely expressed, but a second form of TPH, TPH2, was recently...

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Identifiers

PMID: 15940290
DOI: 10.1038/sj.mp.4001698

Genes

TPH2

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Related research

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Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.PMID 15940290Read ↗

No association between TPH2 gene polymorphisms and ADHD in a UK sample.Semantic proximity Read ↗

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.Semantic proximity Read ↗

Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population.Semantic proximity Read ↗

Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder.Semantic proximity Read ↗

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2Semantic proximity Read ↗

Sex-dependent complex association of TPH2 with multiple dimensions of ADHD.Semantic proximity Read ↗

Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children.Semantic proximity Read ↗

Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population.Semantic proximity Read ↗

Tryptophan hydroxylase-1 gene variants associated with schizophrenia.Semantic proximity Read ↗

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.Semantic proximity Read ↗

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