Article
Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Kähler Anna K, Otnaess Mona K, Wirgenes Katrine V, Hansen Thomas, Jönsson Erik G, Agartz Ingrid, Hall Håkan, Werge Thomas, Morken Gunnar, Mors Ole, Mellerup Erling, Dam Henrik, Koefod Pernille, Melle Ingrid, Steen Vidar M, Andreassen Ole A, Djurovic Srdjan
Abstract excerpt
The phosphodiesterase 4B (PDE4B), which is involved in cognitive function in animal models, is a candidate susceptibility gene for schizophrenia (SZ) and bipolar disorder (BP). Variations in PDE4B have previously been associated with SZ, with a suggested gender-specific effect. We have genotyped and analyzed 40 and 72 tagging single nucleotide polymorphisms (tagSNPs) in SZ and BP multicenter samples,...
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