Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population.

doi:10.1002/ajmg.b.30852

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2009

Numata Shusuke, Iga Jun-Ichi, Nakataki Masahito, Tayoshi Shin'ya, Taniguchi Kyoko, Sumitani Satsuki, Tomotake Masahito, Tanahashi Toshihito, Itakura Mitsuo, Kamegaya Yoko, Tatsumi Masahiko, Sano Akira, Asada Takashi, Kunugi Hiroshi, Ueno Shu-Ichi, Ohmori Tetsuro

Abstract excerpt

The phosphodiesterase 4B (PDE4B) interacts with disrupted-in-schizophrenia 1 (DISC1), which is a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). PDE4B is also important in the regulation of cAMP signaling, a second messenger implicated in learning, memory, and mood. In this study, we determined mRNA expression levels of the PDE4B gene in the peripheral blood...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Share to Depressive Disorder, Major

Share to Gene Expression

Share to Gene Frequency

Share to Haplotypes

Share to Japan

Share to RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 18785206
DOI: 10.1002/ajmg.b.30852

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population.PMID 18785206Read ↗

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population.Semantic proximity Read ↗

Association study of PDE4B with panic disorder in the Japanese population.Semantic proximity Read ↗

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia.Semantic proximity Read ↗

Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies.Semantic proximity Read ↗

Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorderSemantic proximity Read ↗

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.Semantic proximity Read ↗

Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples.Semantic proximity Read ↗

Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.Semantic proximity Read ↗

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.Semantic proximity Read ↗

Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms.Semantic proximity Read ↗

Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese.Semantic proximity Read ↗

Limited association between Disrupted in Schizophrenia 1 (DISC1) gene and bipolar disorder in the Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.