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Article

The PDE4B gene confers sex-specific protection against schizophrenia.

Psychiatric genetics - 1 Jun 2007

Pickard Benjamin S, Thomson Philippa A, Christoforou Andrea, Evans Kathryn L, Morris Stewart W, Porteous David J, Blackwood Douglas H R, Muir Walter J

Abstract excerpt

BACKGROUND: Phosphodiesterase 4B (PDE4B) is a candidate gene for schizophrenia and affective disorders through its disruption by a chromosomal translocation in an individual with schizophrenia, its inhibition by the antidepressant rolipram, and its physical interaction with another key candidate, Disrupted in Schizophrenia (DISC1). OBJECTIVE: To determine the contribution made by PDE4B to the population risk of...

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Source

Identifiers

PMID: 17417055
DOI: 10.1097/YPG.0b013e328014492b

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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