Article
Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder.
Nature communications - 1 Jan 2013
Lencz Todd, Guha Saurav, Liu Chunyu, Rosenfeld Jeffrey, Mukherjee Semanti, DeRosse Pamela, John Majnu, Cheng Lijun, Zhang Chunling, Badner Judith A, Ikeda Masashi, Iwata Nakao, Cichon Sven, Rietschel Marcella, Nöthen Markus M, Cheng A T A, Hodgkinson Colin, Yuan Qiaoping, Kane John M, Lee Annette T, Pisanté Anne, Gregersen Peter K, Pe'er Itsik, Malhotra Anil K, Goldman David, Darvasi Ariel
Abstract excerpt
Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel genome-wide significant risk locus at chromosome 4q26, demonstrating the potential advantages of...
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