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Intestinal flora induces the expression of Cyp3a in the mouse liver

1 Apr 2009

Abstract excerpt

In order to determine the effects of intestinal flora on the expression of cytochrome P450 (CYP), the mRNA expression of CYP was compared between specific pathogen-free (SPF) and germ-free (GF) mice. Most of the major CYP isozymes showed higher expression in the livers of SPF mice compared with GF mice. Nuclear factors such as pregnane X receptor (PXR) and constitutive androstane receptor (CAR), as well as...

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PMID: 19350455
DOI: 10.1080/00498250802651984

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