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Article

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

The Journal of biological chemistry - 5 Jul 2002

Burk Oliver, Tegude Heike, Koch Ina, Hustert Elisabeth, Wolbold Renzo, Glaeser Hartmut, Klein Kathrin, Fromm Martin F, Nuessler Andreas K, Neuhaus Peter, Zanger Ulrich M, Eichelbaum Michel, Wojnowski Leszek

Abstract excerpt

Human CYP3A enzymes play a pivotal role in the metabolism of many drugs, and the variability of their expression among individuals may have a strong impact on the efficacy of drug treatment. However, the individual contributions of the four CYP3A genes to total CYP3A activity remain unclear. To elucidate the role of CYP3A7, we have studied its expression in human liver and intestine. In both organs, expression of...

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Identifiers

PMID: 11940601
DOI: 10.1074/jbc.M202345200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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