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Article

Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2006

Richardson Terrilyn A, Sherman Melanie, Antonovic Leposava, Kardar Sean S, Strobel Henry W, Kalman Daniel, Morgan Edward T

Abstract excerpt

Citrobacter rodentium is the rodent equivalent of human enteropathogenic Escherichia coli infection. This study investigated regulation of hepatic and renal cytochrome P450 (P450) mRNAs, hepatic P450 proteins, cytokines, and acute phase proteins during C. rodentium infection. Female C3H/HeOuJ (HeOu) and C3H/HeJ (HeJ) mice [which lack functional toll-like receptor 4 (TLR4)] were infected with C. rodentium by oral...

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Identifiers

PMID: 16339354
DOI: 10.1124/dmd.105.007393
PMCID: PMC1382008

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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