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Cross-species analysis of hepatic cytochrome P450 and transport protein expression

4 Nov 2020

Abstract excerpt

Most drugs and xenobiotics are metabolized in the liver. Amongst others, different cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of foreign compounds, and various transport proteins are engaged in the excretion of metabolites from the hepatocytes. Inter-species and inter-individual differences in the hepatic levels and activities of drug-metabolizing enzymes and transporters result from genetic...

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PMID: 33150952
DOI: 10.1007/s00204-020-02939-4

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