Gut Microbiome Alters the Activity of Liver Cytochromes P450 in Mice With Sex-Dependent Differences

Abstract excerpt

Sexual differences and composition/function of gut microbiome are not considered as the most important players on drug metabolism field; however, from the recent data is obvious that they may significantly affect the response of patient to therapy. Here, we evaluated the effect of microbial colonization and sex-differences on mRNA expression and enzymatic activity of hepatic cytochromes P450 (CYPs) in germ-free...

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