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Article

Statin therapy inhibits remyelination in the central nervous system.

The American journal of pathology - 1 May 2009

Miron Veronique E, Zehntner Simone P, Kuhlmann Tanja, Ludwin Samuel K, Owens Trevor, Kennedy Timothy E, Bedell Barry J, Antel Jack P

Abstract excerpt

Remyelination of lesions in the central nervous system contributes to neural repair following clinical relapses in multiple sclerosis. Remyelination is initiated by recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) into myelinating oligodendrocytes. Simvastatin, a blood-brain barrier-permeable statin in multiple sclerosis clinical trials, has been shown to impact the in vitro processes...

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Identifiers

PMID: 19349355
DOI: 10.2353/ajpath.2009.080947
PMCID: PMC2671276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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