Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Nature - 11 Jun 2015

Najm Fadi J, Madhavan Mayur, Zaremba Anita, Shick Elizabeth, Karl Robert T, Factor Daniel C, Miller Tyler E, Nevin Zachary S, Kantor Christopher, Sargent Alex, Quick Kevin L, Schlatzer Daniela M, Tang Hong, Papoian Ruben, Brimacombe Kyle R, Shen Min, Boxer Matthew B, Jadhav Ajit, Robinson Andrew P, Podojil Joseph R, Miller Stephen D, Miller Robert H, Tesar Paul J

Abstract excerpt

Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural degeneration and subsequent disability requires remyelination through the generation of new oligodendrocytes, but current treatments exclusively target the immune system. Oligodendrocyte progenitor cells are stem cells in the central nervous system and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Demyelinating Diseases
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelin Sheath

Share to Oligodendroglia

Share to Pluripotent Stem Cells

Share to Receptors, Glucocorticoid

Share to Regeneration

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 25896324
DOI: 10.1038/nature14335
PMCID: PMC4528969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.PMID 25896324Read ↗

High-content phenotypic screening and triaging strategy to identify small molecules driving oligodendrocyte progenitor cell differentiation.Semantic proximity Read ↗

Molecular interventions to overcome the ageing of CNS stem cellsSemantic proximity Read ↗

High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel TargetsSemantic proximity Read ↗

Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival.Semantic proximity Read ↗

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeuticSemantic proximity Read ↗

Drug library screen identifies inhibitors of toxic astrogliosisSemantic proximity Read ↗

An integrated approach to design novel therapeutic interventions for demyelinating disorders.Semantic proximity Read ↗

Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defectSemantic proximity Read ↗

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.Semantic proximity Read ↗

Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantationSemantic proximity Read ↗

Tamoxifen accelerates the repair of demyelinated lesions in the central nervous systemSemantic proximity Read ↗

Rapid and efficient oligodendrocyte differentiation from human pluripotent stem cells via dual inhibition of BMP and Notch signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.