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Nuclear receptor PPARγ targets GPNMB to promote oligodendrocyte development and remyelination

15 Nov 2024

Abstract excerpt

Myelin injury occurs in brain ageing and in several neurological diseases. Failure of spontaneous remyelination is attributable to insufficient differentiation of oligodendrocyte precursor cells (OPCs) into mature myelin-forming oligodendrocytes in CNS demyelinated lesions. Emerging evidence suggests that peroxisome proliferator-activated receptor γ (PPARγ) is the master gatekeeper of CNS injury and repair and...

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PMID: 39756479
DOI: 10.1093/brain/awae378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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