Article

Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination

2026-08-13

Abstract excerpt

Multiple sclerosis is characterized by immune–mediated demyelination and inefficient remyelination, owing to impaired differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes (OLs). Inflammatory cytokines within multiple sclerosis lesions inhibit OPC maturation and induce an immune–like phenotype with antigen–presenting properties, but the underlying mechanisms remain poorly defi...

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Literature Corpus work: 6ad29f85-0aba-5027-b153-ce17ab77e1a8
DOI: 10.64898/2026.08.07.743529

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