Article

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

2020-12-30

Abstract excerpt

<h4>ABSTRACT</h4> The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing the ISR can improve remyelination in an inflammatory environment. To examine this possibility, the remyelination stage of experimental autoimmu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2e67679-9638-5429-810e-0698246da05f
DOI: 10.1101/2020.12.29.424699

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environmentDOI 10.1101/2020.12.29.424699Read

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeuticSemantic proximity Read

An integrated approach to design novel therapeutic interventions for demyelinating disorders.Semantic proximity Read

Targeted Modulation of Inflammatory Lymphocytes and Neurogenesis/Neuroprotection Associated Genes by Curcumin and a Novel Derivative of Curcumin on Mice Experimental Autoimmune Encephalomyelitis ModelSemantic proximity Read

Effects of EHP-101 on inflammation and remyelination in murine models of Multiple SclerosisSemantic proximity Read

Myelination- and immune mediated MR-based brain network correlatesSemantic proximity Read

Effect of CSF1R Inhibitor on Glial Cells Population and Remyelination in The Cuprizone ModelSemantic proximity Read

The Translatability of Multiple Sclerosis Animal Models for Biomarkers Discovery and Their Clinical UseSemantic proximity Read

Repetitive Trans-spinal magnetic stimulation Promotes Repair in Inflammatory Spinal Cord Injury Through Sex-Dependent Immune ModulationSemantic proximity Read

Intraperitoneal injection of mesenchymal stem cells-conditioned media (MSCS-CM) treated monocyte can potentially alleviate motor defects in experimental autoimmune encephalomyelitis female mice; an original experimental studySemantic proximity Read

Teriflunomide as a Therapeutic Means for Myelin RepairSemantic proximity Read

A comparative transcriptomic analysis of mouse demyelination models and Multiple Sclerosis lesionsSemantic proximity Read

Neural Stem Cells Derived From Primitive Mesenchymal Stem Cells Reversed Disease Symptoms and Promoted Neurogenesis in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple SclerosisSemantic proximity Read