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Article

The TWEAK/FN14 axis influences the phenotype of cardiac fibroblasts during pathological cardiac remodeling through the regulation of EGR1.

European journal of pharmacology - 15 Feb 2026

Han Wenqiang, Lan Qingsu, Zhang Runtian, Shen Zimeng, Zhong Jingquan, Hao Li

Abstract excerpt

BACKGROUND: Pathological cardiac remodeling is a critical process in the progression of cardiovascular diseases. To investigate the role and underlying mechanisms of the TWEAK/FN14 axis in cardiac fibrosis, we conducted both in vivo and in vitro experiments. METHODS AND RESULTS: Transcriptomic analysis and Western blotting revealed that FN14 expression was upregulated in animal models of pathological cardiac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41580010
DOI: 10.1016/j.ejphar.2026.178568

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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