Article

TLR2 activates AP-1 to facilitate CTGF transcription and stimulate doxorubicin-induced myocardial injury

2023-07-29

Abstract excerpt

<h4>Objective: </h4> Our study aimed to explore the mechanism network that TLR2/AP-1 combined with SOX10 to activate the MAPK pathway via CTGF in Dox-induced myocardial injury. <h4>Methods:</h4> Rats with Dox-induced myocardial injury were treated with a TLR2 inhibitor or CTGF silencing lentiviral vector. H9c2 cells were treated with genetic vectors or MAPK pathway activators. Cardiac function was tested using ech...

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Literature Corpus work: 474c3021-cdaf-5823-aa7a-4d7b46009b7f
DOI: 10.22541/au.169060516.66116457/v1

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