Article
No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies
15 May 2008
Abstract excerpt
Growing evidence suggests that the tumor necrosis factor superfamily (TNFSF) member TWEAK and its cognate receptor Fn14 play an important role in both physiological and pathological tissue remodeling. Herein, we review the various lines of experimental evidence that support the involvement of this ligand/receptor pair in triggering a wide range of cellular responses crucial to tissue remodeling, including...
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