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Article

Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis.

JAMA neurology - 1 Mar 2018

Apostolova Liana G, Risacher Shannon L, Duran Tugce, Stage Eddie C, Goukasian Naira, West John D, Do Triet M, Grotts Jonathan, Wilhalme Holly, Nho Kwangsik, Phillips Meredith, Elashoff David, Saykin Andrew J

Abstract excerpt

Importance: Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with AD remains unknown. Objective: To investigate the association of the top 20 AD risk variants with brain amyloidosis. Design, Setting, and Participants: This study analyzed the genetic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29340569
DOI: 10.1001/jamaneurol.2017.4198
PMCID: PMC5885860

Genes

ABCA7
FERMT2

Provenance

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