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Article

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia.

Neurology - 22 Jan 2013

Ossenkoppele Rik, van der Flier Wiesje M, Zwan Marissa D, Adriaanse Sofie F, Boellaard Ronald, Windhorst Albert D, Barkhof Frederik, Lammertsma Adriaan A, Scheltens Philip, van Berckel Bart N M

Abstract excerpt

OBJECTIVE: To examine the relationships between apolipoprotein E (APOE) ε4 dose and in vivo distributions of both fibrillary amyloid burden and glucose metabolism in the same Alzheimer disease dementia patients, selected for abnormal amyloid imaging. METHODS: Twenty-two APOE ε4 negative, 40 heterozygous, and 22 homozygous Alzheimer disease dementia patients underwent dynamic (90 minutes) [(11)C]Pittsburgh...

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Source

Identifiers

PMID: 23255822
DOI: 10.1212/WNL.0b013e31827f0889

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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