Article
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.
BioMed research international - 1 Jan 2015
Li Jin, Zhang Qiushi, Chen Feng, Yan Jingwen, Kim Sungeun, Wang Lei, Feng Weixing, Saykin Andrew J, Liang Hong, Shen Li
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Using discrete disease status as the phenotype and computing statistics at the single marker level may not be able to address the underlying biological interactions that contribute to disease mechanism and may contribute to the issue of "missing heritability." We performed a genome-wide association study (GWAS) and a genome-wide interaction...
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