Article
A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus.
The Journal of experimental medicine - 17 May 1999
Chan O T, Hannum L G, Haberman A M, Madaio M P, Shlomchik M J
Abstract excerpt
The precise role of B cells in systemic autoimmunity is incompletely understood. Although B cells are necessary for expression of disease (Chan, O., and M.J. Shlomchik. 1998. J. Immunol. 160:51-59, and Shlomchik, M.J., M.P. Madaio, D. Ni, M. Trounstine, and D. Huszar. 1994. J. Exp. Med. 180:1295-1306), it is unclear whether autoantibody production, antigen presentation, and/or other B cell functions are required...
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