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Article

Roles of interferon-gamma and interleukin-4 in murine lupus.

The Journal of clinical investigation - 15 Apr 1997

Peng S L, Moslehi J, Craft J

Abstract excerpt

The systemic autoimmune syndrome of MRL/Mp-lpr/lpr (MRL/lpr) mice consists of severe pan-isotype hypergammaglobulinemia, autoantibody production, lymphadenopathy, and immune complex-associated end-organ disease. Its pathogenesis has been largely attributed to helper alphabeta T cells that may require critical cytokines to propagate pathogenic autoantibody production. To investigate the roles of prototypical Th1...

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Identifiers

PMID: 9109438
DOI: 10.1172/JCI119361
PMCID: PMC508018

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