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Article

IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice.

Biology direct - 16 Jan 2012

Greenspan Neil S, Lu Myro A, Shipley Jacob W, Ding Xuedong, Li Qing, Sultana Dilara, Kollaros Maria, Schreiber John R, Fu Pingfu, Putterman Chaim, Emancipator Steven N

Abstract excerpt

BACKGROUND: Antibodies of the IgG3 subclass have been implicated in the pathogenesis of the spontaneous glomerulonephritis observed in mice of the MRL/MpJ-Tnfrsf6lpr (MRL/lpr) inbred strain which have been widely studied as a model of systemic lupus erythematosus We have produced IgG3-deficient (-/-) mice with the MRL/lpr genetic background to determine whether IgG3 antibodies are necessary for or at least...

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Identifiers

PMID: 22248284
DOI: 10.1186/1745-6150-7-3
PMCID: PMC3293080

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Source receipt: pubmed, retrieved 7 Sept 2026.

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