Beneficial effects of long-term treatment with SK&F 105685 in murine lupus nephritis.

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Article

Beneficial effects of long-term treatment with SK&F 105685 in murine lupus nephritis.

The Journal of pharmacology and experimental therapeutics - 1 Oct 1990

Albrightson-Winslow C R, Brickson B, King A, Olivera D, Short B, Saunders C, Badger A M

Abstract excerpt

MRL/Mp-lpr/lpr (MRL/lpr) mice were studied from 6 to 19 weeks of age. Proteinuria began to increase at 15 weeks, and continued to increase until the animals were sacrificed at 19 weeks. This proteinuria was associated with lymphadenopathy and splenomegaly, as well as changes in lymph node cell ph...

Topics

Animals
Antibodies, Antinuclear
Autoimmune Diseases
Female
Immunosuppressive Agents
Kidney
Lupus Nephritis
Lymphatic Diseases
Lymphocytes
Mice
Phenotype
Proteinuria
Spiro Compounds
T-Lymphocytes, Regulatory

Source

Open in PubMed

Identifiers

PMID: 2145424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2145424-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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