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Article

Rak functions as a tumor suppressor by regulating PTEN protein stability and function.

Cancer cell - 7 Apr 2009

Yim Eun-Kyoung, Peng Guang, Dai Hui, Hu Ruozhen, Li Kaiyi, Lu Yiling, Mills Gordon B, Meric-Bernstam Funda, Hennessy Bryan T, Craven Rolf J, Lin Shiaw-Yih

Abstract excerpt

Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms. In this study, we demonstrate that the Rak tyrosine kinase physically interacts with PTEN and phosphorylates PTEN on Tyr336. Knockdown of Rak enhanced the binding of PTEN to its E3 ligase NEDD4-1 and promoted PTEN polyubiquitination, leading to PTEN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19345329
DOI: 10.1016/j.ccr.2009.02.012
PMCID: PMC2673492

Genes

PTEN
NEDD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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