Article
Down-regulation of the tumor suppressor gene retinoic acid receptor beta2 through the phosphoinositide 3-kinase/Akt signaling pathway.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2006
Lefebvre Bruno, Brand Céline, Flajollet Sébastien, Lefebvre Philippe
Abstract excerpt
The retinoic acid receptor beta2 (RARbeta2) is a potent, retinoid-inducible tumor suppressor gene, which is a critical molecular relay for retinoid actions in cells. Its down-regulation, or loss of expression, leads to resistance of cancer cells to retinoid treatment. Up to now, no primary mechanism underlying the repression of the RARbeta2 gene expression, hence affecting cellular retinoid sensitivity, has been...
Topics
- Acetylation
- Animals
- Cell Line
- DNA-Binding Proteins
- Dimerization
- Down-Regulation
- Enzyme Activation
- Histones
- Humans
- Mice
- Mutation